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KMID : 0043319980210050508
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Archives of Pharmacal Research
1998 Volume.21 No. 5 p.508 ~ p.513
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Studies on Protective Effect of Da-9601, Artemisia asiatica Extract, on Acetaminophen- and CCI4 induced Liver Damage in Rats
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Ryu Byoung-Kweon
Ahn Byoung-Ok
Oh Tae-Young
Kim Soon-Hoe
Kim Won-Bae
Lee Eun-Bang
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Abstract
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The hepatoprotective effect of DA-9601, a quality-controlled extract of artemisisa asiatica, on liver damage induced by acetaminophen (APAP) and carbon tetrachloride () was investigated by means of serum-biochemical, hepatic-biochemical, and histopathological examinations. Doses of Da-9601 (10, 30, or 100 mg/kg) were administered intragastrically to each rat on three consecutive days i.e. 48 h, 24 h and 2 h before a single administration of APAP (640 mg/kg, i.p.) or (2 ml/kg, p.o.). Four h and 24 h after hepatotoxin treatment, the animals were sacrificed for evaluation of liver damage. Pretreatment of Da-9601 reduced the elevation of serum ALT, AST. LDH and histopathological changes such as centrilobular necrosis, vacuolar degeneration and inflammatory cell infiltration dose-dependently. Da-9601 also prevented APAP- and -induced hepatic glutathione (GSH) depletion and -induced increase of hepatic malondialdehyde (MDA), a parameter of lipid peroxidation, in a chemically induced liver injury by complex mechanisms which involve prevention of lipid peroxidation and preservation of hepatic GSH.
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KEYWORD
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DA-9601, ARTEMISIA ASIATICA, HEPATOPROTECTION, ACETAMINOPHEN, CARBON TETRACHLORIDE, RAT
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